Search Results

The hormonal changes that happen during the menopause can have a dramatic impact on your body. Learning about the connections between your hormones and breast cancer can help you to understand your breast cancer risk and enable you to make the right choices about treatments like hormone replacement therapy (HRT). Breast Cancer Risk and the Menopause The risk of breast cancer increases with age, but there is no suggestion that this is directly because of the menopause. There seems to be more likelihood of developing breast cancer if you started menstruating early (before the age of 12) or if you start the menopause late (after the age of 55) possibly because you will have been exposed to more of these hormones over your lifetime. Using hormonal contraceptives that contain hormones such as oestrogen and progesterone could also have a small effect on your cancer risk. There is some evidence that long-term use of hormonal contraceptives could slightly increase the risk of breast cancer but using these types of contraception can also help to protect you against ovarian cancer. Most women can take hormonal contraceptives safely, but you should discuss the risks and benefits with your doctor. You might decide to choose a different type of contraception if you are already at higher risk of breast cancer due to your family or medical history. Breast Cancer Treatment and Menopausal Symptoms Some kinds of breast cancer treatment such as endocrine therapy (tamoxifen, anastrazole, letrozole), ovarian suppression (goserelin (Zoladex)) and chemotherapy can affect the levels of the hormones that control the menstrual cycle. The menopause is triggered by a decrease in the production of these hormones, so treatments that cause similar drops in hormone levels can lead to the same kinds of symptoms. Sometimes the effects are only temporary, so you may experience some menopause-like symptoms during treatment. However, breast cancer treatment can sometimes trigger the menopause and cause permanent changes. Some women who have the BRCA1 or BRCA2 genes that are associated with both breast and ovarian cancer may decide to have preventative surgery to remove their ovaries, which will lead to menopause. Breast Cancer and HRT Hormone Replacement Therapy (HRT) is very effective in relieving symptoms that some women experience during the menopause. The standard recommendation has been that HRT is not recommended for women who have a history of breast cancer. Recent data suggest that in women who have had a hysterectomy taking oestrogen-only HRT slightly reduces the risk of breast cancer. Those women who have intact uterus are usually given oestrogen and progesterone and they seem to have a slightly higher risk of developing breast cancer. The absolute impact of HRT on your breast cancer risk is fairly small, so if your menopausal symptoms are very severe you might want to discuss the risks and benefits of HRT with your doctor so a balanced judgment about taking HRT can be made. This requires a weighing up the slight future risk with an improvement in quality of life. You can also get advice on other ways of managing your symptoms. These discussions should take place between you and your t

Breast cancer is the most common type of cancer in women. Although we don’t yet know enough to be able to predict who will be affected by cancer, we do know that it can sometimes run in families. We have also identified some genes that can put you at risk of breast cancer. However, that doesn’t mean that all cases of breast cancer are hereditary. In fact, only about 5-10% of breast cancers are likely to be caused by hereditary factors. Family History of Breast Cancer The family history is important, particularly breast and ovarian cancer in women and prostate cancer in men. If you have a close relative (such as a mother or sister) who had breast or ovarian cancer or a male relative had prostate cancer, then you might be more likely to develop breast or ovarian cancer, especially if they were affected at a young age. However, it is important to remember that cancer is very common and that breast cancer is particularly common in women. It is possible for more than one person in the family to be affected by cancer simply by chance, even if they aren’t carrying a gene that puts them at higher risk. Even if someone in your family has had breast cancer, it doesn’t mean that you will develop it too. Genetics and Breast Cancer The chances of developing breast cancer can depend on many different factors, including your age and lifestyle as well as your genes. It is likely that there are many different genes that can affect your chances of developing breast cancer. Some may help to protect you, while others could increase the risk. If there is a history of breast or ovarian cancer in your family, then it could be due to some of these higher risk genes. The two most influential and best understood genes for breast cancer are BRCA1 and BRCA2. Women who carry these genes are at higher risk of developing breast and ovarian cancer. If you have a faulty copy of one of these genes there is up to a 7 in 10 chance that you will be affected by breast cancer by the time you are 80. In the last few years many other genes related to breast cancer have been found. If someone in your family has been tested and found to carry the BRCA1 or BRCA2 genes then there is a chance you may be carrying them too. However, there is only a 1 in 2 chance of the gene being passed on from parent to child. If your mother has one of these genes then there is a 50% chance that you have it too. What Should You Do If You’re at Risk of Breast Cancer? If you have a family history of breast cancer then it is a good idea to talk to a doctor or genetic counsellor, especially if a relative has tested positive for BRCA1 or BRCA2. You will get personalised advice on your risk and whether you should be tested for these genes. You can also learn more about preventative treatments that could help to reduce the risks if you do have these genes.

The hormonal changes that happen during the menopause can have a dramatic impact on your body. Learning about the connections between your hormones and breast cancer can help you to understand your breast cancer risk and enable you to make the right choices about treatments like HRT. Breast Cancer Risk and the Menopause The risk of breast cancer increases with age, but there is no suggestion that this is directly because of the menopause. There seems to be more likelihood of developingbreast cancer if you started menstruating early (before the age of 12) or if you start the menopause late (after the age of 55) possibly because you will have been exposed to more of these hormones over your lifetime. Using hormonal contraceptives that contain hormones such as oestrogen and progesterone could also have a small effect on your cancer risk.There is some evidence that long-term use of hormonal contraceptives could slightly increase the risk of breast cancer but using these types of contraception can also help to protect you against ovarian cancer. Most women can take hormonal contraceptives safely, but you should discuss the risks and benefits with your doctor. You might decide to choose a different type of contraception if you are already at higher risk of breast cancer due to your family or medical history. Breast Cancer Treatment and Menopausal Symptoms Some kinds of breast cancer treatment such as hormone therapy, ovarian suppression and chemotherapy can affect the levels of the hormones that control the menstrual cycle. The menopause is triggered by a decrease in the production of these hormones, so treatments that cause similar drops in hormone levels can lead to the same kinds of symptoms. Sometimes the effects are only temporary, so you may experience some menopause-like symptoms during treatment. However, breast cancer treatment can sometimes trigger the menopause and cause permanent changes. Some women who have the BRCA1 or BRCA2 genes that are associated with both breast and ovarian cancer may decide to have preventative surgery to remove their ovaries, which will lead to menopause. Breast Cancer and HRT Hormone Replacement Therapy (HRT) is very effective in relieving symptoms that some women experience during the menopause. The standard recommendation has been that HRT is not recommended for women who have a history of breast cancer. Recent data suggest that in women who have had a hysterectomy taking oestrogen-only HRT slightly reduces the risk of breast cancer. Those women who have intact uterus are usually given oestrogen and progesterone and they seem to have a slightly higher risk of developing breast cancer. The absolute impact of HRT on your breast cancer risk is fairly small, so if your menopausal symptoms are very severe you might want to discuss the risks and benefits of HRT with your doctor so a balanced judgment about taking HRT can be made. You can also get advice on other ways of managing your symptoms.

Breast cancer is the most common type of cancer in women. Although we don’t yet know enough to be able to predict who will be affected by cancer, we do know that it can sometimes run in families. We have also identified some genes that can put you at risk of breast cancer. However, that doesn’t mean that all cases of breast cancer are hereditary. In fact, only about 5-10% of breast cancers are likely to be caused by hereditary factors. Family History of Breast Cancer The family history is important, particularly breast and ovarian cancer in women and prostate cancer in men. If you have a close relative (such as a mother or sister) who had breast or ovarian cancer or a male relative had prostate cancer, then you might be more likely to develop breast or ovarian cancer, especially if they were affected at a young age. However, it is important to remember that cancer is very common and that breast cancer is particularly common in women. It is possible for more than one person in the family to be affected by cancer simply by chance, even if they aren’t carrying a gene that puts them at higher risk. Even if someone in your family has had breast cancer, it doesn’t mean that you will develop it too. Genetics and Breast Cancer The chances of developing breast cancer can depend on many different factors, including your age and lifestyle as well as your genes. It is likely that there are many different genes that can affect your chances of developing breast cancer. Some may help to protect you, while others could increase the risk. If there is a history of breast or ovarian cancer in your family, then it could be due to some of these higher risk genes. The two most influential and best understood genes for breast cancer are BRCA1 and BRCA2. Women who carry these genes are at higher risk of developing breast and ovarian cancer. If you have a faulty copy of one of these genes there is up to a 7 in 10 chance that you will be affected by breast cancer by the time you are 80. If someone in your family has been tested and found to carry the BRCA1 or BRCA2 genes then there is a chance you may be carrying them too. However, there is only a 1 in 2 chance of the gene being passed on from parent to child. If your mother has one of these genes then there is a 50% chance that you have it too. What Should You Do If You’re at Risk of Breast Cancer? If you have a family history of breast cancer then it is a good idea to talk to a doctor or genetic counsellor, especially if a relative has tested positive for BRCA1 or BRCA2. You will get personalised advice on your risk and whether you should be tested for these genes. You can also learn more about preventative treatments that could help to reduce the risks if you do have these genes.

Newspapers Daily Telegraph: A revolution in breast cancer therapy Results from a major trial of TARGIT are published today in The Lancet, and suggest that it could revolutionise breast cancer treatment. TARGIT Telegraph e-paper – The Daily Telegraph – 11 Nov 2013 – Page #26 Daily Mail: One-stop breast cancer treatment: Radiation breakthrough will help thousands Herald Scotland: Radiotherapy after surgery could aid breast cancer recovery Daily Mail: Me and my operation: The one-stop breast cancer op that spares women weeks of radiotherapy Actual A3 size ​ Other Medical Journals ​ Nature Reviews Clinical Oncology: Research Highlights Targeted intraoperative radiotherapy – one pit stop for breast cancer treatment ​ News channels on the web ​ ASCO POST Targeted Intraoperative Radiotherapy Concurrent With Lumpectomy Non-inferior to External-Beam Radiotherapy in Preventing Local Breast Cancer Recurrence MedPage Today: Radiation at Surgery Equal to Whole-Breast RT Medscape: ‘One-Stop’ Radiotherapy Saves Time With Breast Cancer ​ Medical News Today: Breast cancer radiotherapy during surgery could ease treatment The Information Daily: Targeted radiotherapy during surgery vital for breast cancer recovery Doctors Lounge: Intraoperative Radiotherapy Promising for Breast Cancer ​Monthly Prescribing Reference: Intraoperative Radiotherapy Promising for Breast Cancer News-Medical.net: Targeted radiotherapy could offer viable alternative to current … Medical Research.com Breast Cancer: Intraoperative vs Whole Breast Radiotherapy medicalphysicsweb Targeted radiotherapy is a viable option ​ ecancerNews “One-stop” radiotherapy could offer an alternative to lengthy and inconvenient post-surgery procedures for breast cancer Today Topics “One-stop” radiotherapy could offer an alternative to lengthy and inconvenient post-surgery procedures for breast cancer Irish Medical Times One-stop radiotherapy for breast cancer Institution news ​ UCL News New system of radiotherapy ​ UCLH News Single dose radiotherapy could transform breast cancer care: A ‘single shot’ of radiation could revolutionise breast cancer treatment in the NHS according to the findings of a 13-year study. ​ Whittington Health News ‘One-step’ procedure may offer alternative to lengthy radiotherapy sessions and Catchup Newletter PDF National Institute of Health Research Department of Health Intraoperative Radiation for Breast Cancer Study in The Lancet Altmetrics which measures online attention, as of 18 November 2013, puts this paper in 99% centile of all 1.6 million papers it has ever tracked – and it is in the 98% centile amongst all articles in the Lancet – click here to see the latest Altmetric on the TARGIT-A 2013 Lancet paper Television Central Chinese Television – British “one-stop” breast cancer treatment can shorten the course of radiotherapy for breast cancer TARGIT for Breast Cancer AudioMedica | Oncology Times | MDFM news: BREAST CANCER: Intraoperative radiotherapy at the time of lumpectomy is as effective as whole breast irradiation with fewer non-cancer deaths

25 July 2014 : NICE issued a press release that prompted the following media coverage of TARGIT IORT for breast cancer with Intrabeam ​ Newspaper articles Single-dose radiotherapy eases breast cancer stress The Times ​ Thousands of women with breast cancer will be offered a new form of radiotherapy to spare them weeks of gruelling treatment. The half-hour treatment is carried out at the same time as surgery, and trials showed that women found it easier, quicker and less … Half-hour breast cancer treatment can replace weeks of radiotherapy … Daily Mail – ‎Jul 24, 2014‎ ​ Tens of thousands of women with breast cancer could soon be offered a single 30-minute shot of radiotherapy, sparing them weeks of exhausting treatment. The new treatment called intrabeam radiotherapy is delivered during surgery, while the patient is still … NICE gives go ahead to intrabeam radiotherapy for breast cancer The BMJ – ‎Jul 29, 2014‎ ​ Intrabeam radiotherapy, a single dose treatment used during surgery for patients with breast cancer, has been given the go ahead for use in the NHS in England. More newpaper articles Single-dose radiotherapy could transform breast cancer treatment The Guardian – ‎Jul 25, 2014‎ Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In draft guidance, the National Institute for Health and Care excellence (Nice) said the treatment option should be considered for people with early … NHS approves one-shot breast cancer therapy treatment The Independent – ‎Jul 25, 2014‎ ‘Intrabeam‘ radiotherapy involves injecting a single shot of radiation inside the breast during surgery, meaning patients with early breast cancer do not have to keep attending treatment sessions. Early stage breast cancer is classed as such when the tumour is … Cancer therapy on offer more widely Swindon Advertiser – ‎Jul 25, 2014‎ PIONEERING breast cancer treatment will be available to up to 150 women with any type of tumour and of any age across Swindon on the NHS, it has been announced. Earlier this year, the Great Western Hospital launched an appeal to fund new … UK to adopt Indian-origin expert’s breast cancer treatment Hindustan Times – ‎17 hours ago‎ Carole Longson, director National Institute for Health and Care Excellence, said on Friday: “Unlike regular radiotherapy, with the intrabeam radiotherapy system only one dose is required. This single dose is given at the same time as surgery, eliminating the … BBC 6pm News: Breast cancer: One-shot therapy gets NHS nod A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. BBC TV: Marcelle Bernstein: No side effects from breast cancer treatment Marcelle Bernstein talks about the pioneering breast cancer treatment she received two years ago which is to be offered on the NHS. BBC: Breast cancer: One-shot therapy gets NHS nod Health / 25 July 2014 A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose… New radiotherapy ‘eliminates need for numerous visits’ ITV News – ‎Jul 24, 2014‎ Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses … ​ ‘Innovative’ radiotherapy for breast cancer sufferers ITV News – ‎Jul 24, 2014‎ The National Institute for Health and Care excellence (Nice) gave intrabeam radiotherapy the seal of approval for use on the NHS. The treatment involves administering a single dose of radiotherapy to patients during surgery. A single dose of radiotherapy … Single dose radiotherapy approved for breast cancer sufferers ITV News – ‎Jul 24, 2014‎ An “innovative” form of radiotherapy for patients in the early stages of breast cancer has been approved on the NHS. The National Institute for Health and Care excellence (Nice) gave the green light for “revolutionary” intrabeam radiotherapy. Share · Tweet … Single-Shot Radiotherapy For Breast Cancer Sky News – ‎Jul 24, 2014‎ Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer. For breast cancer patients like me, the age of refinement is truly transforming The Guardian – ‎Jul 25, 2014‎ Single-dose radiotherapy could transform breast cancer treatment. Intrabeam radiotherapy, which has go-ahead for NHS use, is given during surgery, eliminating need for additional hospital trips. Published: 25 Jul 2014 … Intrabeam radiotherapy, boon for breast cancer patients Delhi Daily News – ‎Jul 25, 2014‎ Professor Carole Longson, director of health technology evaluation at Nice, said in a statement: “It’s still a new treatment – so far only six centres in the UK have used the Intrabeam Radiotherapy System to treat early breast cancer. Because it is still relatively … ‘Revolutionary’ new cancer therapy Harborough Mail – ‎Jul 24, 2014‎ Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional … ‘One stop’ breast cancer surgery wins NHS go-ahead Express.co.uk – ‎Jul 25, 2014‎ The revolutionary laser treatment could transform the way doctors treat early stage breast cancer and save the health service £50million. Charities hailed the decision as “exciting” and said that often the Intrabeam radiotherapy is the only treatment women … One dose therapy for some breast cancer patients WebMD.Boots.com – ‎Jul 25, 2014‎ 25th July 2014 – A new one-shot radiotherapy treatment for breast cancer patients has been provisionally recommended for use by the NHS in England. Intraoperative radiotherapy (IORT) using the Intrabeam Radiotherapy System, is administered from inside … ‘Revolutionary’ breast cancer therapy wins NHS backing Halifax Evening Courier – ‎Jul 25, 2014‎ Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer. NICE to OK single-shot radiotherapy for breast cancer PharmaTimes – ‎Jul 24, 2014‎ NICE has, however, stipulated that doctors must fully inform patients of all their treatment choices so that they can make informed decisions, enter details about all of those treatment with intrabeam radiotherapy onto a national register, and audit, review and … Breast cancer: ‘revolutionary’ one-shot treatment for NHS The Week UK – ‎Jul 25, 2014‎ “It’s still a new treatment – so far only six centres in the UK have used the Intrabeam radiotherapy system to treat early breast cancer,” says Professor Carole Longson, director of health technology evaluation at Nice. “Because it is still relatively new it is only … Breakthrough breast cancer treatment given the go-ahead The Voice of Russia – ‎Jul 25, 2014‎ The new treatment is a single dose of radiotherapy administered during a patient’s cancer surgery that will eliminate the need for multiple radiotherapy follow-up sessions. Intrabeam radiotherapy has been given the go-ahead for NHS use and will soon be … New breast cancer treatment can tackle disease in one day Irish Mirror – ‎Jul 25, 2014‎ Thousands of women with breast cancer could benefit from a new treatment that tackles the disease in a day. Intrabeam radiotherapy is an X-ray device that blasts a high dose of radiation directly into a tumour. Draft guidance from the National Institute for … News digest July 25 2014 Nursing Standard – ‎Jul 25, 2014‎ Tens of thousands of breast cancer patients could benefit from a new type of radiotherapy that could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use … Breast cancer zapped by fast new radiotherapy Shiny Shiny – ‎Jul 25, 2014‎ After a tumour is removed, doctors use the intrabeam radiotherapy system to insert a probe into the breast and deliver a concentrated dose of radiation directly to the site of the malignancy. A trial on 2000 women led by a UK team found that this had a similar … Breast cancer: Single-shot therapy to be offered on NHS Metro – ‎Jul 25, 2014‎ A new treatment for breast cancer that consists of a single shot is set to be available on the NHS. The technique, known as intra-operative radiation, concentrates a dose of radiation that is injected from inside the breast during surgery, once a tumour has been … NHS Approves “One Shot” Cancer Blast to Replace Weeks of Radiotherapy Gizmodo UK – ‎Jul 25, 2014‎ The group that decides what treatments are allowed to be dished out by the NHS has approved a new form of radiation treatment, with the intra-operative radiation therapy hopefully providing a one-time blast to obliterate the remnants of breast cancer in those … ‘Revolutionary’ breast cancer therapy wins NHS backing Todmorden Today – ‎Jul 25, 2014‎ Tens of thousands of breast cancer sufferers could benefit from a “revolutionary” new type of radiotherapy delivered during surgery. Intrabeam radiotherapy has been given a provisional go-ahead for NHS use for people with early-stage breast cancer. Breast cancer: One-shot therapy gets NHS nod The Guardian Nigeria – ‎Jul 24, 2014‎ A pioneering breast cancer treatment that replaces weeks of radiotherapy with a single, targeted shot is set to be offered on the NHS. The dose of radiation is delivered from inside the breast, once a tumour has been removed in surgery. It would benefit up to … ‘Revolutionary’ single-dose breast cancer treatment begins in UK BreakingNews.ie – ‎Jul 24, 2014‎ Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment.Intrabeam radiotherapy has been given a provisional … Single-Shot Radiotherapy For Breast Cancer City Talk 105.9 – ‎Jul 24, 2014‎ Intrabeam radiotherapy has been given provisional go-ahead for NHS use by the National Institute for Health and Care excellence (Nice). In new draft guidance, Nice said the treatment option should be considered for people with early stage breast cancer. ‘Revolutionary’ new cancer therapy Belfast Telegraph – ‎Jul 24, 2014‎ Intrabeam radiotherapy has been given a provisional go-ahead for NHS use by the health finance watchdog. In new draft guidance, the National Institute for Health and Care excellence (Nice) said that the treatment option should be considered for people with … cancer therapy ITN – ‎Jul 25, 2014‎ Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional … NHS gave a green signal for the revolutionary new breast cancer therapy The Football Examiner – ‎Jul 24, 2014‎ Tens of thousands of breast cancer sufferers could benefit from an “innovative” new type of radiotherapy which could be delivered during surgery instead of making them take a course of treatment. Intrabeam radiotherapy has been given a provisional … New radiotherapy ‘eliminates need for numerous visits’ ITV News – ‎Jul 24, 2014‎ Unlike regular radiotherapy, with the Intrabeam Radiotherapy System only one dose is required. This single dose is given at the same time as surgery, eliminating the need for numerous hospital visits. Regular radiotherapy typically requires numerous doses … ​ Health – My Free Britain ​ www.myfreebritain.com/health ​ Mirror, Footballer association, Chartered Society of Physiotherapy, Chinese Xinmin,Netherlands zeikenhuis, Turkey Trk TURK, Spain El Semanario, Greece IATRONET,Brazil Journal dia dia, Brazil A Tarde, 9NewsChannel.

The Wall Street Journal, 25 Aug 2015 features TARGIT IORT for breast cancer The main article: Alternative Way to Treat Early-Stage Breast Cancer With Radiation TARGIT-IORT-featured-in-The-Wall-Street-Journal-25-August-2015.pdf The author Melinda Becks explains in a video interview below New Thinking on Radiation for Breast Cancer Treatment. The West Australian: Breast Cancer Breakthrough- Revolution in radiotherapy , 31 August 2015 From 1 September 2015, women with breast cancer in Australia can now get access to Medicare-funded TARGIT IORT

BMJ Blog British Medical Journal – BMJ – May 10, 2016 ​ More Virtues of One-Stop Radiotherapy for Breast Cancer Medscape – May 10, 2016 Treating breast cancer patients with single-dose targeted intraoperative radiotherapy (TARGIT) at the time of surgery substantially reduces the burden on patients’ lives and on the environment in comparison with traditional radiotherapy, an analysis by … ​ ​ Intra-operative Radiation For Breast Cancer Better For Patients and Environment MedicalResearch.com (blog) – May 9, 2016 Prof. Vaidya: TARGIT-A randomised clinical trial (ISRCTN34086741) compared giving TARGIT IORT during lumpectomy vs. traditional EBRT given … ​ ​ Targeted radiotherapy during surgery cuts breast cancer patients’ travel – study BT.com – ‎May 9, 2016‎ Giving breast cancer patients a targeted dose of radiotherapy during surgery would save them millions of miles travelling to and from hospital appointments, according to a study. The procedure, which is widely available in other countries but not on … ​ Radiotherapy during breast cancer surgery cuts cost and time OnMedica – ‎May 10, 2016 Giving patients undergoing surgery for early-stage breast cancer a single, targeted intraoperative dose of radiotherapy saves women hundreds of miles and many hours of travel, costs and fuel and has the potential to cut the UK’s carbon dioxide (CO2) … Radiotherapy during surgery could save millions of travel miles and tons of CO2 Medical Xpress – ‎May 9, 2016‎ One targeted dose of radiotherapy given during surgery to remove early stage breast cancer could save millions of travel miles, enough CO2 emissions for a 100 hectare forest, and free up thousands of hours of women’s time, concludes research published … ​ Radiotherapy technique ‘cuts patient travel times’ World First Travel Insurance – May 10, 2016 Breast cancer sufferers could save themselves unnecessary long journeys if Britain adopted a radiotherapyprocedure already used by several other countries, a report claims. Patients waste “unnecessary” journeys averaging out at 100 miles and nearly … ​ ​ Targeted radiotherapy during surgery cuts breast cancer patients’ travel – study Daily Mail – By Press Association – May 9th 2016, 11:14:58 pm Giving breast cancer patients a targeted dose of radiotherapy during surgery would save them millions of miles travelling to and from hospital appointments, … ​ Breast cancer find reduces radiotherapy: Single high-powered shot given during surgery could help 20,000 patients avoid weeks of daily treatment Daily Mail – Health By Ben Spencer, Health Correspondent- May 9th 2016, 10:58:39 pm High powered intrabeam radiotherapy, delivered during surgery while a patient is still under anaesthetic, takes as little as 20 minutes (file photo). ​ Radiotherapy during surgery could save millions of travel miles and tons of CO2 EurekAlert (press release) – ‎May 9, 2016‎ One targeted dose of radiotherapy given during surgery to remove early stage breast cancer could save millions of travel miles, enough CO2 emissions for a 100 hectare forest, and free up thousands of hours of women’s time, concludes research published … ​ Targeted radiotherapy during surgery cuts breast cancer patients’ travel – study South Wales Guardian – ‎May 9, 2016‎ Under current standard treatment for breast cancer, the cancerous tissue is cut out in a procedure known as a lumpectomy and patients then undergo a course of daily radiotherapy lasting three to six weeks. But under an alternative form of treatment ..

BBC Inside Health programme 5 and 6 July 2016 ​ Intrabeam |TARGIT IORT discussion starts at 12:14 min ​ http://www.bbc.co.uk/programmes/b07j537l ​

NICE Recommendation of Intrabeam TARGIT IORT for breast cancer NICE tweet about their recommendation of Intrabeam for breast cancer ​ British Medical Journal: NICE recommends controlled intrabeam use for breast cancer after three year delay bmj.j725.full_.pdf BreastCancerNow: Intrabeam TARGIT IORT gives better quality of life ​ Daily Mirror: Thousands of women with early breast cancer should receive radiotherapy with surgery ​ DailyMail: Blast of radiation you get DURING operation for breast cancer could spare patients weeks of gruelling treatment ActionRadiotherapy LiveWire: Intrabeam TARGIT IORT effective” Swindon Advertiser: GWH cancer project will save 120 women trip to Oxford each year BBC Wiltshire coverage of Intrabeam TARGIT IORT PharmaTimes: NICE backs targeted breast cancer therapy Indian Express about Intrabeam TARGIT IORT

In January 2018, a paper was published in the British Medical Journal with the following key messages: https://www.bmj.com/content/360/bmj.j5913 Key messages Neoadjuvant chemotherapy is being increasingly used for breast cancer despite higher rates of local recurrence and no evidence of survival benefit, mainly because of the immediate and dramatic pathological responses seen with newer drugs The increased pathological response of the primary tumour does not translate into a survival benefit even when given in the adjuvant setting, challenging the paradigm of “window of opportunity” studies We must acknowledge that neoadjuvant chemotherapy may not be beneficial to patients We should consider reducing the widespread use of neoadjuvant chemotherapy The full paper can be accessed at http://discovery.ucl.ac.uk/10041365/ and along with discussions at Rethinking neoadjuvant chemotherapy for breast cancer – full text and subsequent discussion Discussed at the British Association of Surgical Oncologists- BASO-ACS – NCRI 2018 conference, Glasgow, UK, 4 November 2018

Full text download Neoadjuvant-chemotherapy-for-breast-cancer-BMJ-13-Jan-2018-p-66-68-print-and-online-versions-1.pdf http://www.bmj.com/content/360/bmj.j5913 Key Messages Neoadjuvant chemotherapy is being increasingly used for breast cancer despite higher rates of local recurrence and no evidence of survival benefit, mainly because of the immediate and dramatic pathological responses seen with newer drugs The increased pathological response of the primary tumour does not translate into a survival benefit even when given in the adjuvant setting, challenging the paradigm of “window of opportunity” studies We must acknowledge that neoadjuvant chemotherapy may not be beneficial to patients We should consider reducing the widespread use of neoadjuvant chemotherapy